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Ronald Fisher
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„He has made contributions to many areas of science; among them are agronomy, anthropology, astronomy, bacteriology, botany, economics, forestry, meteorology, psychology, public health, and-above all-genetics, in which he is recognized as one of the leaders. Out of this varied scientific research and his skill in mathematics, he has evolved systematic principles for the interpretation of empirical data; and he has founded a science of experimental design. On the foundations he has laid down, there has been erected a structure of statistical techniques that are used whenever people attempt to learn about nature from experiment and observation.“
„Natural Selection is not evolution.“
„The academic mind, as we know, is sometimes capable of assuming an aggressive attitude. The official mind, on the contrary, is and has to be, expert in the art of self-defence.“
„In scientific subjects, the natural remedy for dogmatism has been found in research. By temperament and training, the research worker is the antithesis of the pundit. What he is actively and constantly aware of is his ignorance, not his knowledge; the insufficiency of his concepts, of the terms and phrases in which he tries to excogitate his problems: not their final and exhaustive sufficiency. He is, therefore, usually only a good teacher for the few who wish to use their mind as a workshop, rather than a warehouse.“
„No efforts of mine could avail to make the book easy reading.“
„Professor Eddington has recently remarked that ‘The law that entropy always increases — the second law of thermodynamics — holds, I think, the supreme position among the laws of nature’. It is not a little instructive that so similar a law [the fundamental theorem of natural selection] should hold the supreme position among the biological sciences.“
„In organisms of all kinds the young are launched upon their careers endowed with a certain amount of biological capital derived from their parents. This varies enormously in amount in different species, but, in all, there has been, before the offspring is able to lead an independent existence, a certain expenditure of nutriment in addition, almost universally, to some expenditure of time or activity, which the parents are induced by their instincts to make for the advantage of their young. Let us consider the reproductive value of these offspring at the moment when this parental expenditure on their behalf has just ceased. If we consider the aggregate of an entire generation of such offspring it is clear that the total reproductive value of the males in this group is exactly equal to the total value of all the females, because each sex must supply half the ancestry of all future generations of the species. From this it follows that the sex ratio will so adjust itself, under the influence of Natural Selection, that the total parental expenditure incurred in respect of children of each sex, shall be equal; for if this were not so and the total expenditure incurred in producing males, for instance, were less than the total expenditure incurred in producing females, then since the total reproductive value of the males is equal to that of the females, it would follow that those parents, the innate tendencies of which caused them to produce males in excess, would, for the same expenditure, produce a greater amount of reproductive value; and in consequence would be the progenitors of a larger fraction of future generations than would parents having a congenital bias towards the production of females. Selection would thus raise the sex-ratio until the expenditure upon males became equal to that upon females.“
„I believe that no one who is familiar, either with mathematical advances in other fields, or with the range of special biological conditions to be considered, would ever conceive that everything could be summed up in a single mathematical formula, however complex.“
„… the best causes tend to attract to their support the worst arguments, which seems to be equally true in the intellectual and in the moral sense.“
„…it was Darwin’s chief contribution, not only to Biology but to the whole of natural science, to have brought to light a process by which contingencies a priori improbable, are given, in the process of time, an increasing probability, until it is their non-occurrence rather than their occurrence which becomes highly improbable. … Let the reader … attempt to calculate the prior probability that a hundred generations of his ancestry in the direct male line should each have left at least one son. The odds against such a contingency as it would have appeared to his hundredth ancestor (about the time of King Solomon) would require for their expression forty- four figures of the decimal notation; yet this improbable event has certainly happened.“
„… the so-called co-efficient of heritability, which I regard as one of those unfortunate short-cuts, which have often emerged in biometry for lack of a more thorough analysis of the data.“
„Faith Is Not Credulity.“
„However, perhaps the main point is that you are under no obligation to analyse variance into its parts if it does not come apart easily, and its unwillingness to do so naturally indicates that one’s line of approach is not very fruitful.“
„Natural selection is a mechanism for generating an exceedingly high degree of improbability.“
„The million, million, million … to one chance happens once in a million, million, million … times no matter how surprised we may be that it results in us.“
„More attention to the History of Science is needed, as much by scientists as by historians, and especially by biologists, and this should mean a deliberate attempt to understand the thoughts of the great masters of the past, to see in what circumstances or intellectual milieu their ideas were formed, where they took the wrong turning or stopped short on the right track.“
„There is, then, in this analysis of variance no indication of any other than innate and heritable factors at work. (Coining of the phrase ‘analysis of variance’.)“
„To consult the statistician after an experiment is finished is often merely to ask him to conduct a post mortem examination. He can perhaps say what the experiment died of.“
„(Coining the phrase ‘test of significance’): Critical tests of this kind may be called tests of significance, and when such tests are available we may discover whether a second sample is or is not significantly different from the first.“
„[…] the uncontrolled causes which may influence the result are always strictly innumerable.“
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